Oil-in-water-in-oil (o/w/o) type multiple emulsions on the other hand consist of very small droplets of oil dispersed in the water globules of a water-in-oil emulsion.Īpplication of Multiple emulsion- Sustained release of Drug– the drug that is incorporated in the innermost phase must cross to face boundaries before getting absorbed. Oil-in-water-in-oil (o 1/w/o 2) emulsion.Įmulsifying a w/o emulsion using water-soluble surfactants (which stabilize an oily dispersed phase) can produce w/o/w emulsions with an external aqueous phase, which generally has a lower viscosity than the primary w/o emulsion.Water-in-oil-in-water (w 1/o/w 2) emulsion. Multiple emulsions can be classified as the following They can be considered as emulsions within emulsions. Multiple emulsions are emulsions whose dispersed phase contains droplets of another emulsion. Fine emulsionįine emulsion have a milky appearance and the globules size range from 0.25 to 25 µm (micrometre). So microemulsions are transparent in appearance. Oil-in-water emulsion formulations are useful for the parenteral administration of drugs which have significant delivery problems. This extends the classical definition to include liquid droplets and/or liquid crystals dispersed in liquid 2. The emulsion is thermodynamically unstable. of drug and strength of middle membrane phase, which is a multimolecular layer of oil, water and emulsifier at both the interfaces of multiple emulsion, controls the drug release from these systems. Droplets ranging in diameter (0.1-100 um). Keywords: Microemulsion, multiple emulsion, multiple emulsions, nanoemulsion oil/water, oil-in- water-in-oil. Droplets of such dimensions cannot refract light and as a result, globules are invisible to the naked eye. An emulsion is a liquid preparation containing two immiscible liquids, one of which is dispersed as globules (dispersed phase internal phase) in the other liquid (continuous phase external phase). in-water and water-in-oil emulsions exists simultaneously, stabilized by. Micro-emulsion contains globules of size about 0.01 µm. School of Studies in Pharmaceutical Sciences, Jiwaji University, Gwalior. Spray congealing technique was exploited to produce solid lipid microparticles (SLMp) loaded with a highly water-soluble drug (metoclopramide hydrochloride). Depending on particle/globules size of the internal phase, pharmaceutical emulsions can be classified as 1.
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